Ovine multiparity is associated with diminished vaginal muscularis, increased elastic fibres and vaginal wall weakness: implication for pelvic organ prolapse
نویسندگان
چکیده
منابع مشابه
Ovine multiparity is associated with diminished vaginal muscularis, increased elastic fibres and vaginal wall weakness: implication for pelvic organ prolapse
Pelvic Organ Prolapse (POP) is a major clinical burden affecting 25% of women, with vaginal delivery a major contributing factor. We hypothesised that increasing parity weakens the vagina by altering the extracellular matrix proteins and smooth muscle thereby leading to POP vulnerability. We used a modified POP-quantification (POP-Q) system and a novel pressure sensor to measure vaginal wall we...
متن کاملDiminished vaginal HOXA13 expression in women with pelvic organ prolapse.
OBJECTIVE Homeobox genes are transcriptional regulators that orchestrate embryonic development. The HOXA13 gene is responsible for the development of the vagina and regulates extracellular matrix constituents. We hypothesized that vaginal expression of HOXA13 may be decreased in women with pelvic organ prolapse (POP) and sought to determine if hypoestrogenism affects its expression. METHODS B...
متن کاملChanges in Muscularis Propria of Anterior Vaginal Wall in Women with Pelvic Organ Prolapse
The objective of this study was to evaluate the morphological and immunohistochemical alterations of tissue removed from the upper third of anterior vaginal wall in a sample group of the female population presenting homogenous risk factors associated with Pelvic Organ Prolapse (POP). The case study consisted of 14 patients with POP and there were 10 patients in the control group. Patient select...
متن کاملIncreased Elastin Content in the Vaginal Wall of Postmenopausal Women with Pelvic Organ Prolapse
Hypothesis / aims of study Changes in elastin content have been linked to the pathophysiology of pelvic organ prolapse (POP), however it is unclear whether the elastin content is increased [1] or decreased [2,3]. Such discrepancies could be attributed to differences in biopsy site, kind of analysis and/or patient population. Our study is the first to perform an extended biochemical analysis of ...
متن کاملInsertion and removal of vaginal mesh for pelvic organ prolapse.
A variety of surgical meshes are available to correct pelvic organ prolapse. This article discusses benefits and risks of vaginal mesh use. Emphasis is placed on the appropriate surgical technique to improve outcomes and minimize mesh complications. Placement options are reviewed with the discussion of self-tailored mesh, trocar-based mesh kits, and non-trocar mesh kits. This article also revie...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/srep45709